Curcumin of turmeric root
The benefits of turmericCurcumin (diferuloylmethane), demethoxycurcumin and bisdemethoxycurcumin form the group of curcuminoids and come from turmeric ( Curcuma longa ), traditionally used as a spice in Indian and Southeast Asian cuisine. These are also the components coloring the curry powder. In Asian countries, curcumin is also used as a natural remedy for inflammations, but also for liver, stomach and intestines problems.
The curcumin is one of the most studied natural substances: more than 9,000 clinical and preclinical trials have now been devoted to this natural remedy.
Curcumin against cancer
Curcumin has an anti-carcinogenic effect because it prevents the proliferation of different cancer cells. It also inhibits
transcription factors NF-kappaB, AP-1 and Egr-1
the production of COX2, LOX, NOS, MMP-9, uPA, TNF-α,
but also chemokines, cell adhesion molecules, cyclin D1, kinases such as NK and tyrosine and serine / threonine kinases and growth factors such as EGFR and HER2, related to the most varied cell signaling pathways .
Curcumin strengthens the antioxidant protection system and has an anti-inflammatory effect through the inhibition of NF-kappaB factor. It is further assumed that it can prevent not only the formation of tumors but also their metastatization (Aggarwal et al., 2003).
Studies on curcumin have shown that intestinal polyps, the early stage of bowel or rather colon cancer, are significantly less common in patients with familial adenomatous polyposis (Giardiello et al., 2006).
Curcumin inhibits metastasis formation in breast cancer and is particularly effective when combined with paclitaxel (Aggarwal et al., 2005). It also inhibits the enzyme glyoxalase 1, forming levorotatory lactic acid, in aggressive cancer cells and thus reduces the lactic acid production of cancer cells (Santel et al., 2008). Lactic acid laevogyre protects the tumor, favoring metastatization.
Bioavailability of Curcumin
Despite the extremely high level of preclinical testing, the clinical use of curcumin has gained in importance in recent years. The reason is that although curcuminoids are extremely effective molecules, their bioavailability is very low and they are very quickly metabolized by the liver. It is therefore not easy to achieve clinically significant efficacy - and only clinical effects matter, not cell culture.
Curcumin is a fat-soluble molecule and the ideal is to consume it during a meal containing fat, as is the case in India and Ayurveda .
The curcumin bonds dissolved in fat are then resorbed by the lymph, pass into the blood via the thoracic duct ( ductus thoracicus ) and thus bypass the rapid metabolism in the liver. On the contrary, when curcumin is absorbed with water, its bioavailability is almost nil.
In many products, the fat soluble curcumin molecule is embedded in chemical emulsifiers, such as polysorbate 80 ; their curcumin content is therefore low. This combination forms so-called micelles , that is, molecules soluble in water. These connections are not absorbed by the lymph, but directly by the blood system, in the intestine. They then pass through the portal vein to reach the liver directly, where they are metabolized. They reach their maximum concentration after 1 hour and it then falls rapidly.
These mechanisms also explain why the effects are poor in the studies conducted, despite the high bioavailability achieved by this formulation of curcumin (Schiborr et al., 2014) (Dützmann et al., 2016, Kocher et al. 2016, see Tables 1 and 2).
Comparison of composition, bioavailability, and status of studies for different curcumin formulations
Comparison of AUC Values for Different Curcumin Formulations by Curcumin Dose
A study in animals has shown that the polysorbate 80 emulsifier promotes inflammation of the intestine. It therefore promotes the development of inflammatory bowel diseases and the metabolic syndrome. In addition to a modification of the intestinal flora, emulsifiers have the effect of reducing the gap between the intestinal bacteria and the intestinal epithelium, protected by a layer of mucus (Chassaing et al., 2015). It is not known at present whether these results are transposable to humans.
A piperine extract is also often used to increase the bioavailability of curcumin. The most important study relating to the bioavailability of curcumin when absorbed with piperine shows that a 2,000 mg dose of curcumin has a 20-fold greater bioavailability when piperine is added (Shoba et al. , 1998). The serum values thus achieved were, however, still well below the values reached in case of absorption of a curcumin-phospholipid complex (see Table 2).
The great disadvantage of piperine is that it inhibits the detoxification enzymes CYP (phase I and phase II) and therefore also the metabolism of drugs (Atal et al., 1985, Bhardwaj et al., 2002, Franceschi et al., 2015, Gurley et al., 2012). Resorption also takes place via the intestine and the portal vein.
The absorption by the lymph is similar to that practiced for millennia in Ayurvedic medicine and cooking with the galenic form of turmeric dissolved in ghee.
The combination of curcumin with a phospholipid to form a complex is therefore very interesting: according to a randomized double-blind study, a phospholipid-curcumin complex would have a bioavailability 29 times greater than that of traditional curcumin (Cuomo et al., 2011)
Combined with natural phospholipids, curcumin is able to penetrate cell membranes and access the interior of cells. The bioavailability of curcumin, however, can vary greatly depending on its preparation and the design of the study (with or without meals, type of meal, etc.), only the evidence of clinical efficiencies are decisive for the preparations based on curcumin.
Breast cancer: turmeric and pepper could fight it
Breast cancer: turmeric and pepper could fight it
MEDICINE CANCER BREAST CANCER GOOD FOODS
Turmeric and pepper may be useful in treating breast cancer by limiting the growth of stem cells that make the tumor swell.
Turmeric and pepper have long been studied as potential treatments for cancer, but this new study suggests for the first time that these spices could prevent cancer by specifically targeting stem cells.
Cancer can come back and develop because conventional chemotherapy does not eliminate cancer stem cells. Researchers at the University of Michigan Cancer Center in the United States have discovered that when curcumin, a chemical found in turmeric, and piperine, which comes from black pepper, are added to a cell culture, the number of stem cells is reduced while normal cells are spared. The derivatives were tested on breast cells at a dose 20 times higher in power than what would be consumed during meals.
Researchers believe that eliminating cancer stem cells and reducing the number of normal cells are essential in the fight against cancer.
Piperine enhances the effects of curcumin, and both elements halt the process of renewal of cancer stem cells.
"It shows that these compounds are not toxic to normal breast tissue," says Madhuri Kakarala, a lecturer in internal medicine at the University of Michigan School of Medicine, lead author of the study. "Women who are at high risk of breast cancer can currently choose to take preventive treatment with tamoxifen or raloxifene, but most women do not take these drugs because they are too toxic. help is seductive, and curcumin and piperine seem to have very low toxicity. "
These two compounds are still being studied, for their possible role in the treatment of cancer, researchers note that we should not add more curcumin or pepper to its diet.
Curcumin is known for many other health benefits, especially in Asian medicine. It is used to treat gastrointestinal problems and arthritis, and is also a powerful antioxidant.
Piperine has anti-inflammatory properties, and is known to improve digestion. It is often used in slimming diets. Piperine also improves nutrient absorption when it comes with other foods.
Top Curcumin Brand of Choice
Dietox is a natural health brand which relies on healthy people and a healthy lifestyle. Beyond the eco-friendly juice detox therapy , nutrition trends are finally beginning to put forward exotic ingredients with thousands of health benefits.
Dietox, always on the cutting edge, has focused on the power of one of these ingredients to create its new product that promises to be indispensable in your refrigerator: 7 shots of turmeric .
What is turmeric?
Turmeric is a spice derived from a plant of the family Zingiberaceae that is grown in Asia, especially in India.
The extract of this plant has been used for centuries as a food coloring (turmeric is famous for its particular yellow-orange color), mainly for cooking curry. But because of its curcuminoid content, turmeric is also credited with powerful medicinal uses .
The science has relied on it many times and there are many studies (the US National Institutes of Health have registered 71 clinical trials with turmeric) that have demonstrated the effectiveness of this ingredient for the treatment of diseases digestive, hepatic, as well as arthritis or certain types of cancer.
What are the 7 shots of Dietox turmeric?
Given the healing power of turmeric and its powerful health benefits , Dietox has developed a 7-shot pack of turmeric so you can add nutrients to your daily routine with a miraculous effect on your body.
If you order the Fresh Shot of Dietox Turmeric , you will receive a bag containing 7 mini small bottles of 60 ml each. Each shot is made from pineapple juice, turmeric juice, lemon juice and black pepper .
Black pepper is essential in the mix because it ensures good absorption by the body.
What are the 7 top medicinal benefits of curcumin?
These 7 incredible benefits that your health will enjoy when you discover the Fresh Shot of Turmeric.
Antioxidant: slows the first signs of aging
Anticancer: According to Bharat Aggarwal, Professor of Cancer Medicine at the University of Texas MD Anderson Cancer Center, curcumin inhibits the development of many types of cancer.
Anti-inflammatory: Curcumin helps reduce inflammation of the respiratory tract and urinary tract.
Antidepressant: Studies from the University of Michigan have shown that turmeric supplementation in patients with depression improves their mood.
Digestive: acts as a tonic of the stomach, avoids slow and heavy digestions, calms acidity and prevents gastritis.
Burns fat: activates metabolism, helps maintain ideal weight and lowers cholesterol.
Immunoprotective: it is a natural activator of defenses and helps fight infections. In addition, turmeric acts as a protective agent for the liver and helps eliminate gallstones.
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